翻訳と辞書 Words near each other ・ Fibro (disambiguation) ・ Fibro-Adipose Vascular Anomaly ・ Fibroadenoma ・ Fibrobacter succinogenes ・ Fibrobacteres ・ Fibroblast ・ Fibroblast activation protein, alpha ・ Fibroblast growth factor ・ Fibroblast growth factor 23 ・ Fibroblast growth factor receptor ・ Fibroblast growth factor receptor 1 ・ Fibroblast growth factor receptor 2 ・ Fibroblast growth factor receptor 3 ・ Fibroblast growth factor receptor 4 ・ Fibroblast growth factor receptor-like 1 ・ Fibroblast-like synoviocyte ・ Fibrocalculous pancreatopathy ・ Fibrocartilage ・ Fibrocartilage callus ・ Fibrocartilaginous mesenchymoma of bone ・ Fibrochondrogenesis ・ Fibrocystic breast changes ・ Fibrocystin ・ Fibrocyte ・ Fibrodontia ・ Fibrodysplasia ・ Fibrodysplasia ossificans progressiva ・ Fibroepithelial neoplasms ・ Fibrofolliculoma ・ Fibroid Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Fibroblast-like synoviocyte ： ウィキペディア英語版 Fibroblast-like synoviocyte Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a crucial role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. == Fibroblast-like synoviocytes in normal tissues == The inner lining of the joint consists of the synovium (also called the synovial membrane), a thin layer located between the joint capsule and the joint cavity. The word "synovium" is derived from the word "synovia" (or synovial fluid), which is a clear, viscous fluid produced by the synovium, and its main purpose is to reduce friction between the joint cartilages during movement. Synovium is also important to maintain proper joint function by providing the structural support and supply of the necessary nutrients to the surrounding cartilage. Synovial membrane is divided into two compartments – the outer layer (subintima) and the inner layer (intima). The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast-like synoviocytes, which are important in maintaining the internal joint homeostasis. These cells represent the main source of hyaluronic acid and also other glycoproteins, major components of the synovial fluid. Fibroblast-like synoviocytes are cells of mesenchymal origin that display many characteristics common with fibroblasts, such as expression of several types of collagens and protein vimentin, a part of cytoskeletal filaments. Unlike fibroblasts, fibroblast-like synoviocytes also secrete unique proteins, that are normally absent in other fibroblast lineages. These include especially lubricin, a protein crucial for the joint lubrication. Furthermore these cells express a number of molecules important for the mediation of the cell adhesion, such as cadherin-11, VCAM-1, various integrins and their receptors. Specific for fibroblast-like synoviocytes is also the expression of CD55; this protein is often used to identify this cell type in the synovium by immunohistochemistry. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fibroblast-like synoviocyte」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.